Molecular Stamping s.r.l.

Responsible scientists: Dr. Davide Dattilo
Number of employees: 11

Role and contribution to the project:

Molecular Stamping is responsible for all aspects of the project related to the Supramolecular NanoStamping (SuNS) process. We have developed preliminary technologies for the enzymatic regeneration step of the printing cycle, as well as for prototype replica surface preparation. As the project commences, Molecular Stamping will begin transferring these technologies to the laboratories of Pål Nyrén and Harm-Anton Klok, respectively. Throughout the project, all stamping experiments, as well as production of beta product, will be carried out by Molecular Stamping.

Capacity of the organisation to carry out the work:

Molecular Stamping was founded with the aim of providing tools and services to uniquely enable the biotechnology and medical industries. Our core technology, Supramolecular NanoStamping (SuNS), is an extremely robust and versatile method for printing biological molecules onto a substrate with nanometer scale resolution. The inventor of SuNS, Professor Francesco Stellacci at the Massachusetts Institute of Technology, remains an important scientific advisor to the company. Molecular Stamping is currently being hosted by two research institutions in Italy, Parco Tecnologico Padano in Lodi, as well as the Fondazione Bruno Kessler in Povo (which houses a fully equipped class 100 clean room). Twelve full time scientists are currently employed by the company, with two sets of offices and lab spaces. In addition, Molecular Stamping owns a Marathon inkject microarray printer (ArrayJet; Edinburgh), two sets of Genomics Solutions hybridization stations and Perkin Elmer ScanArray GX microarray scanners. We are in the process of installing two class 10,000 clean rooms, which will be dedicated to the production of SuNS arrays.

Qualifications, experience and knowledge of key scientists:

Andrea Cuppoletti PhD is the Director of Chemistry at Molecular Stamping. He came to the company from Affymetrix, where he was a Scientist in the Chemistry Department developing alternative and improved photoactivatable protecting groups for the photolithographic synthesis of high density DNA arrays. More recently he was in the group that developed a novel technology for fabrication of DNA arrays with sub-micron feature sizes. Prior to that Andrea held a postdoctoral research associate position at Stanford University, working on the synthesis and design of non natural nucleosides and their use as either fluorescent tags or probes for polymerase fidelity requirements. Andrea received his Laurea degree from the University of Rome and MS and PhD from the University of Rochester in New York.

Relevant patents:

Cuppoletti, Andrea; Mcgall, Glenn H. “Methods for releasing probes from arrays.” PCT Int. Appl. (2004), WO 2004059010, A1 20040715.

Cuppoletti, Andrea; McGall, Glenn H. “Releasable polymer arrays.” U.S. Pat. Appl. Publ. (2004), US 2004248162, A1 20041209.


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