Royal Institute of Technology, University of Stockholm

Number of employees: 3100

KTH, the Royal Institute of Technology, accounts for one-third of Sweden’s technical research and engineering education capacity at university level. Education and research cover a broad spectrum – from natural sciences to all the branches of engineering. In addition to the research carried out by KTH’s Schools, a large number of both national and local Competence Centres are located at KTH. Various research foundations also finance a number of research programmes. The school of Biotechnology at KTH has an extensive research program involving about 220 employees and PhD students, and large number of courses for a 4.5 years undergraduate teaching programme in Biotechnology.

Qualifications, experience and knowledge of key scientists:

Pål Nyrén PhD has been Professor of Biochemistry at KTH since 1999. Professor Nyrén obtained his PhD at the University of Stockholm in 1985, after a postdoctoral appointment at Cambridge working in the group of Prof. Walker he joined the Faculty of the University of Stockholm in 1988.
Prof. Nyrén is the inventor of pyrosequencing, which has become one of the most important DNA sequencing methods in use today. Based on this technology, he helped to found Biotage AB, formerly known as Pyrosequencing AB. Prof. Nyrén has a number of ongoing research projects in his lab which are primarily focused on applied enzymology.

Relevant Publications

S. Svantesson, P.O. Westermark, J. Hellgren Kotaleski, B. Gharizadeh, A. Lansner and P. Nyrén (2004) A mathematical model of the Pyrosequencing reaction system. Biophysical Chemistry 110, 129-145.

B. Gharizadeh, M. Ghaderi, D. Donnelly, K-L. Wallin, and P. Nyrén (2003) Multiple-primer DNA sequencing method. Electrophoresis, 24, 1145-1151.

T.Nordström, A. Alderborn, and P. Nyrén (2002) Method for one-step preparation of double-stranded DNA template applicable for use with Pyrosequencing technology. J. Biochem. Biophys. Methods 52, 71-82.

B. Gharizadeh, T. Nordström, A. Ahmadian, M. Ronaghi and P. Nyrén (2001) Long read pyrosequencing using pure 2’-deoxyadenosine-5’-O’-(1-thiotriphosphate) Sp-isomer. Anal. Biochem. 301, 82-90.

B. Gharizadeh, M. Kalantari, C. Garcia, B. Johansson, and P. Nyrén (2001) Typing of human papillomavirus (HPV) by pyrosequencing. Laboratory Investigation 81, 673-679.


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